Saturday April 16, Malaga

Saturday April 16, Malaga

00.01 - 23.59
WCO-IOF-ESCEO
08.00 - 09.00
NON-SPONSORED SYMPOSIA
Meeting Room 3
DXA Pitfalls and Tips: FRAX and TBS Integration into acquisition and analysis routine
Chairperson: ‣ Bruno Muzzi Camargos
‣ Dual X-Ray absorptiometry basic principles Ben‑Hur Albergaria
‣ FRAX Cristiano A. F. Zerbini
‣ TBS Bruno Muzzi Camargos
Meeting Room 1
Cancer treatment induced bone loss (CTIBL) in women with breast cancer
Chairpersons: ‣ Peyman Hadji, ‣ René Rizzoli
‣ Risk factors for fractures in women with breast cancer Jean‑Jacques Body
‣ Current treatment guidelines and intervention options Peyman Hadji
‣ Additive effects of antiresorptive treatments beyond osteoporosis Robert E. Coleman
Meeting Room 5
FRAX International experience with an international tool
Chairperson: ‣ John A. Kanis
‣ Introduction - FRAX in the world today John A. Kanis
‣ Frax in USA - How FRAX influenced the way clinicians treat osteoporosis Michael R. McClung
‣ Frax in Latin America - An evaluation of FRAX in Latin America - Should we make calibration for different races? Patricia Clark
‣ FRAX in Europe - Development and the next steps Eugene McCloskey
Meeting Room 2
The clinical value of bone turnover marker assays: latest developments from the IFCC-IOF working group and NBHA
Chairperson: ‣ Robert Gagel
‣ Welcome Robert Gagel
‣ Pathophysiology and variability of bone turnover markers Howard Morris
‣ Standard reference markers – clinical role and research goals for harmonization and standardization Stuart Silverman
‣ IOF and IFCC harmonization of bone turnover markers Howard Morris
‣ NBHA bone turnover marker standardization project Stuart Silverman
‣ Question and answer session Robert Gagel
‣ Conclusion Robert Gagel
Meeting Room 4
Frailty, Falls and Fractures: identification and treatment of the dysmobility syndrome in older persons
Chairperson: ‣ Neil Binkley
‣ Muscle and bone interactions: the biology of osteosarcopenia and dysmobility Gustavo Duque
‣ Potential clinical approaches to the diagnosis of osteosarcopenia/dysmobility Neil Binkley
‣ Therapeutic interventions for osteosarcopenia: current evidence and future directions Cristina Alonso Bouzon
09.00 - 12.10
Auditorium 1
SCIENTIFIC SESSION III
Chairpersons: ‣ Olivier Bruyère, ‣ Eugene McCloskey
09.00
Auditorium 1
Plenary Lecture 5
‣ Vitamin D, immune response and infection Peter R. Ebeling
09.30
Auditorium 1
Presentation of the IOF Medal of Achievement
‣ Cyrus Cooper
09.40
Auditorium 1
Oral communications selected from abstracts
09.40
Auditorium 1
OC18
‣ VITAMIN D MEASUREMENT STANDARDIZATION: THE WAY OUT OF THE CHAOS
Presenting author: ‣ N. Binkley
Authors: ‣ B. Dawson‑Hughes, ‣ R. Durazo‑Arvizu, ‣ M. Thamm, ‣ J. Merkel, ‣ C. T. Sempos
09.50
Auditorium 1
OC19
‣ DETERMINANTS OF THE MATERNAL RESPONSE TO VITAMIN D SUPPLEMENTATION DURING PREGNANCY: THE MAVIDOS TRIAL
Presenting author: ‣ N. C. Harvey
Authors: ‣ R. J. Moon, ‣ S. D'angelo, ‣ S. R. Crozier, ‣ I. Schoenmakers, ‣ N. J. Bishop, ‣ S. Kennedy, ‣ A. T. Papageorghiou, ‣ R. Fraser, ‣ S. V. Gandhi, ‣ A. Prentice, ‣ C. Cooper, ‣ K. Javaid
10.00
Auditorium 1
OC20
‣ EFFICACY OF ODANACATIB IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS: SUBGROUP ANALYSES OF DATA FROM THE PHASE 3 LONG-TERM ODANACATIB FRACTURE TRIAL (LOFT)
Presenting author: ‣ K. G. Saag
Authors: ‣ P. Alexandersen, ‣ C.‑L. Benhamou, ‣ N. Gilchrist, ‣ J. Halse, ‣ E. M. Lewiecki, ‣ K. Lippuner, ‣ M. R. McClung, ‣ M. Shiraki, ‣ C. A. DaSilva, ‣ N. Verbruggen, ‣ B. B. Scott, ‣ A. Lombardi
10.10
Auditorium 1
OC21
‣ DYSMOBILITY SYNDROME AND MORTALITY RISK IN OLDER CHILEAN PEOPLE
Presenting author: ‣ C. Albala
Authors: ‣ L. Lera, ‣ B. Angel, ‣ H. Sanchez, ‣ C. Marquez, ‣ P. Arroyo
10.20
Auditorium 1
OC22
‣ EFFECT OF TREATMENT ON BACK PAIN AND BACK EXTENSOR STRENGTH WITH A SPINAL ORTHOSIS IN ELDERLY WOMEN WITH OSTEOPOROSIS: A RANDOMIZED CONTROLLED TRIAL
Presenting author: ‣ K. Kaijser Alin
Authors: ‣ A.‑L. Grahn Kronhed, ‣ E. Uzunel, ‣ H. Alinaghizadeh, ‣ H. Salminen
10.30
Auditorium 1
OC23
‣ BASELINE AND PERSISTENT KNEE SYMPTOMS ARE INDEPENDENT PREDICTORS OF STRUCTURAL PROGRESSION OF KNEE OSTEOARTHRITIS
Presenting author: ‣ J. Martel‑Pelletier
Authors: ‣ A. J.  Teichtahl, ‣ F. Cicuttini, ‣ Y. Wang, ‣ F. Abram, ‣ J.‑P. Pelletier
10.40
Auditorium 1
Plenary Lecture 6
‣ Diabetoporosis and fat tissues Serge Ferrari
11.10
Auditorium 1
Oral communications selected from abstracts
11.10
Auditorium 1
OC24
‣ THE FUTURE PREVALENCE OF SARCOPENIA IN EUROPE
Presenting author: ‣ O. Ethgen
Authors: ‣ C. Tchokonte, ‣ C. Beaudart, ‣ F. Buckinx, ‣ J.‑Y. Reginster, ‣ O. Bruyère
11.20
Auditorium 1
OC25
‣ SARCOPENIA DEFINITION PARAMETERS AND INCIDENT DISABILITY
Presenting author: ‣ L. A. Schaap
Authors: ‣ E. M. Simonsick, ‣ A. B.  Newman, ‣ A. V. Schwartz, ‣ P. Caserotti, ‣ S. B. Kritchevsky, ‣ B. H. Goodpaster, ‣ T. B. Harris, ‣ M. Visser
11.30
Auditorium 1
OC26
‣ ASSESSMENT OF MUSCLE/LEAN MASS MEASUREMENT: COMPARISON OF METHODS FOR SARCOPENIA DETERMINATION
Presenting author: ‣ N. Binkley
Authors: ‣ B. Buehring, ‣ E. Fidler, ‣ H. Yamada, ‣ D. Krueger, ‣ M. Shankaran, ‣ G. Czerwieniec, ‣ C. Fessler, ‣ W. Evans, ‣ S. Turner, ‣ M. Hellerstein, ‣ D. Schoeller
11.40
Auditorium 1
OC27
‣ AMONG ADULTS AGED 50-64 YEARS, FRAILTY AND SARCOPENIA ARE IMPORTANTLY ASSOCIATED WITH PREMATURE WORKLESSNESS
Presenting author: ‣ K. Walker‑Bone
Authors: ‣ K. T. Palmer, ‣ D. Coggon, ‣ S. D'angelo, ‣ A. A. Sayer, ‣ C. Cooper, ‣ C. Linaker, ‣ E. C. Harris
11.50
Auditorium 1
OC28
‣ PREVALENCE OF SARCOPENIA IN A POPULATION OF NURSING HOME RESIDENTS ACCORDING TO THEIR FRAILTY STATUS: RESULTS OF THE SENIOR COHORT
Presenting author: ‣ F. Buckinx
Authors: ‣ J.‑Y. Reginster, ‣ C. Beaudart, ‣ J.‑L. Croisier, ‣ J. Petermans, ‣ O. Bruyère
12.00
Auditorium 1
OC29
‣ EVALUATION OF THE INTRA-INDIVIDUAL VARIABILITY OF MYOSTATIN AND ACTIVIN A, TWO BIOMARKERS OF SARCOPENIA: IMPACT ON THE LEAST SIGNIFICANT CHANGE AND FOLLOW-UP OF THE PATIENTS
Presenting author: ‣ E. Cavalier
Authors: ‣ C. Piron, ‣ F. Watar, ‣ S. Kovacs, ‣ C. Beaudart, ‣ F. Buckinx, ‣ O. Bruyère, ‣ C. Le Goff, ‣ J.‑Y. Reginster
14.00 - 15.00
Poster Area
Poster Viewing Session II (P451 and above)
14.00 - 15.10
Podium
Oral presentation of selected posters
Chairperson: ‣ Jean‑Pierre Devogelaer
14.00
Podium
P899
‣ SUN EXPOSURE, SKIN COLOR AND VITAMIN D STATUS IN ARAB CHILDREN AND ADULTS
Presenting author: ‣ Y. Al‑Saleh
Authors: ‣ N. Al‑Daghri, ‣ N. Khan, ‣ S. Sabico, ‣ N. Aljohani, ‣ H. Alfawaz, ‣ M. Alsulaimani, ‣ A. Al‑Othman, ‣ M. Alokail
14.07
Podium
P311
‣ CALCIUM AND VITAMIN D SUPPLEMENTATION ARE NOT ASSOCIATED WITH INCREASED RISK OF ISCHAEMIC CARDIAC EVENTS: RESULTS FROM UK BIOBANK
Presenting author: ‣ N. C. Harvey
Authors: ‣ S. D'angelo, ‣ J. Paccou, ‣ M. H. Edwards, ‣ S. E. Petersen, ‣ C. Cooper
14.14
Podium
P653
‣ NEW CARTILAGE QUALITY EVALUATION USING CYCLIC NANO INDENTATION: CASE STUDY WITH A TOOL DMOAD COMPOUND ACTIVE IN THE RAT MNX MODEL
Presenting author: ‣ C. Lavet
Authors: ‣ P. Clement‑Lacroix, ‣ D. Merciris, ‣ S. Meurisse, ‣ L. Lespecheux, ‣ V. Gaillard, ‣ P. Pastoureau, ‣ P. Deprez, ‣ D. Amantini, ‣ P. Ammann
14.21
Podium
P561
‣ REFERENCE POINT MICROINDENTATION FOR SUPPLEMENTING FRACTURE RISK ASSESSMENT AT THE FEMORAL NECK
Presenting author: ‣ P. J. Thurner
Authors: ‣ T. Jenkins, ‣ L. V.  Coutts, ‣ S. D'angelo, ‣ D. G. Dunlop, ‣ R. Oreffo, ‣ C. Cooper, ‣ N. C. Harvey
14.28
Podium
P438
‣ PRIMARY CULTURES OF HUMAN SKELETAL MUSCLE SATELLITE CELLS: A NOVEL MODEL TO ASSESS SKELETAL MUSCLE CELL DIFFERENTIATION
Presenting author: ‣ L. Cianferotti
Authors: ‣ C. Romagnoli, ‣ M. Vigna, ‣ R. Zonefrati, ‣ C. Mavilia, ‣ G. Galli, ‣ M. Innocenti, ‣ G. Marcucci, ‣ A. Tanini, ‣ M. L. Brandi
14.35
Podium
P387
‣ AGE-RELATED TRAJECTORIES OF MUSCLE MASS AND FUNCTION IN ITALIAN COMMUNITY-DWELLERS VISITING THE MILAN EXPO: RESULTS FROM THE VIP STUDY
Presenting author: ‣ M. Tosato
Authors: ‣ R. Calvani, ‣ E. Marzetti, ‣ G. Savera, ‣ A. Collamati, ‣ A. Sisto, ‣ E. Ortolani, ‣ A. M. Martone, ‣ R. Bernabei, ‣ F. Landi
14.42
Podium
P379
‣ ENGLISH TRANSLATION AND CROSS-CULTURAL ADAPTATION OF THE SARQOL® QUESTIONNAIRE
Presenting author: ‣ C. Beaudart
Authors: ‣ M. H. Edwards, ‣ E. M. Dennison, ‣ C. Moss, ‣ O. Bruyère, ‣ J.‑Y. Reginster, ‣ R. J. Moon, ‣ C. Cooper, ‣ C. Demoulin
14.49
Podium
P367
‣ SARCOPENIA AND HIGH RISK OF NONVERTEBRAL FRACTURE IN OLDER MEN: THE STRAMBO STUDY
Presenting author: ‣ P. S. Szulc
Author: ‣ R. D. Chapurlat
14.56
Podium
P325
‣ MUSCLE MASS PREDICTS INCIDENT FRACTURE IN POSTMENOPAUSAL WOMEN: THE OFELY STUDY
Presenting author: ‣ E. Sornay‑Rendu
Authors: ‣ F. Duboeuf, ‣ S. Boutroy, ‣ R. D. Chapurlat
15.03
Podium
P250
‣ A COMPARATIVE STUDY OF THE EFFECTS OF PTH FORMULATIONS ON JAPANESE PATIENTS WITH OSTEOPOROSIS
Presenting author: ‣ H. Kikuchi
Authors: ‣ Y. Itoh, ‣ W. Shimada, ‣ N. Okada, ‣ S. Soen
14.00 - 15.00
MEET-THE-EXPERT SESSIONS (supported by an unrestricted educational grant from UCB Biopharma)
Meeting Room 6
Rare bone diseases
‣ Maria Luisa Brandi
Meeting Room 4
Post-fracture care
‣ Andreas Kurth
Meeting Room 2
Bone strength assessment for the non-initiated
‣ Philippe K. Zysset
Meeting Room 5
Secondary osteoporosis
‣ Jaime Branco
Meeting Room 1
Can we have targets in osteoporosis treatment?
‣ Serge Ferrari
Meeting Room 3
Is Sclerostin an appropriate target for the treatment of osteoporosis?
‣ Michael R. McClung
14.00 - 15.00
ESCEO SYMPOSIA
Conference Room 2.2
Diacerein in the management of osteoarthritis: facts or fantasy
Chairpersons: ‣ Jordi Monfort, ‣ Karel Pavelka
‣ Welcome Jordi Monfort
‣ Preclinical evidence supporting the mode of action of diacerein in osteoarthritis Johanne Martel‑Pelletier
‣ Efficacy of diacerein in the management of osteoarthritis Burkhard Leeb
‣ Safety and risk/benefit ratio of diacerein in the management of osteoarthritis Jean‑Pierre Pelletier
‣ Discussion - Leader Emmanuel Maheu
‣ Conclusions Karel Pavelka
Panel: ‣ Olivier Bruyère, ‣ Cyrus Cooper, ‣ John A. Kanis, ‣ Burkhard Leeb, ‣ Emmanuel Maheu, ‣ Johanne Martel‑Pelletier, ‣ Jordi Monfort, ‣ Karel Pavelka, ‣ Jean‑Pierre Pelletier, ‣ Jean‑Yves Reginster, ‣ René Rizzoli
Conference Room 2.1
Biological and imaging (MRI, DXA,…) markers in the assessment and management of sarcopenia in daily practice
Chairpersons: ‣ Yves Rolland, ‣ Roger A. Fielding
‣ Welcome and Introduction Roger A. Fielding
‣ Evaluation of the sarcopenic patients: The role of primary versus secondary care physicians Antonio Cherubini
‣ Role of markers in the assessment and management of sarcopenia in daily practice: presentation of the ESCEO Experts Consensus Matteo Cesari
‣ Discussion - Leader Francesco Landi
Panel: ‣ Islene Araujo de Carvalho, ‣ Jürgen Bauer, ‣ Ivan Bautmans, ‣ Charlotte Beaudart, ‣ Maria Luisa Brandi, ‣ Olivier Bruyère, ‣ Nansa Burlet, ‣ Etienne Cavalier, ‣ Francesca Cerreta, ‣ Matteo Cesari, ‣ Antonio Cherubini, ‣ Cyrus Cooper, ‣ Alfonso Cruz Jentoft, ‣ Roger A. Fielding, ‣ Evelien Gielen, ‣ John A. Kanis, ‣ Jean‑Marc Kaufman, ‣ Francesco Landi, ‣ Andrea Laslop, ‣ Stefania Maggi, ‣ Eugene McCloskey, ‣ Jean Petermans, ‣ Jean‑Yves Reginster, ‣ René Rizzoli, ‣ Yves Rolland, ‣ Marjolein Visser
15.00 - 17.00
Auditorium 1
SCIENTIFIC SESSION IV
Chairpersons: ‣ Cyrus Cooper, ‣ Jean‑Marc Kaufman
15.00
Auditorium 1
Plenary Lecture 7
‣ Diet, microbiome and bone René Rizzoli
15.30
Auditorium 1
Presentation of the ESCEO-AgNovos Healthcare Young Investigator Awards
‣ Maria Luisa Brandi, ‣ James Howe
15.40
Auditorium 1
Oral communications selected from abstracts
15.40
Auditorium 1
OC30
‣ DISTAL RADIUS CORTICAL MICROSTRUCTURE AND CALCULATED STRENGTH PREDICT INCIDENT FRACTURES INDEPENDENTLY OF FRAX IN POSTMENOPAUSAL WOMEN
Presenting author: ‣ E. Biver
Authors: ‣ C. Durosier, ‣ T. Chevalley, ‣ B. van Rietbergen, ‣ R. Rizzoli, ‣ S. Ferrari
15.50
Auditorium 1
OC31
‣ SWEDISH FARMERS HAVE LOWER RISK FOR HIP FRACTURE THAN EXPECTED FROM ECONOMIC STATUS, EDUCATION AND LOCATION
Presenting author: ‣ H. Johansson
Authors: ‣ C. H. Vala, ‣ A. Odén, ‣ M. Lorentzon, ‣ E. V. McCloskey, ‣ J. A. Kanis, ‣ S. Lohmander, ‣ J. Kärrholm, ‣ D. Mellström
16.00
Auditorium 1
OC32
‣ WITHIN AND ACROSS-SEX INHERITANCE OF BONE MICROARCHITECTURE
Presenting author: ‣ S. Ferrari
Authors: ‣ J. Pepe, ‣ E. Biver, ‣ N. Bonnet, ‣ T. Chevalley, ‣ R. Rizzoli
16.10
Auditorium 1
OC33
‣ IMMINENT FRACTURE RISK IN ELDERLY OSTEOPOROTIC WOMEN: UNDERLYING RELATIONSHIPS BETWEEN RISK FACTORS AND OUTCOME
Presenting author: ‣ R. Barron
Authors: ‣ D. Weycker, ‣ A. Kartashov, ‣ J. Edelsberg, ‣ J. Lani, ‣ A. Grauer, ‣ D. B. Crittenden
16.20
Auditorium 1
OC34
‣ FEMORAL NECK BMD IS STILL THE PREFERRED SITE IN THE ASSESSMENT OF HIP FRACTURE IN ELDERLY MEN (10-YEAR FOLLOW-UP OF MROS SWEDEN)
Presenting author: ‣ H. Johansson
Authors: ‣ A. Odén, ‣ M. K. Karlsson, ‣ M. Lorentzon, ‣ J. A. Kanis, ‣ B. E. Rosengren, ‣ D. Mellström, ‣ O. Ljunggren, ‣ C. Ohlsson, ‣ N. C. Harvey, ‣ E. V. McCloskey
16.30
Auditorium 1
Plenary Lecture 8
‣ Defining sarcopenia Bess Dawson‑Hughes
15.00 - 16.45
Conference Room 2.2
Committee of National Societies Special Plenary Session
‣ Advances in Bone, Muscle and Joint Health
Chairperson: ‣ Jean‑Yves Reginster
15.03
Conference Room 2.2
OCs1
‣ THE INFLUENCE OF OSTEOPOROSIS ON WELL-BEING IN MEN
Presenting author: ‣ D. M. Farcas
Authors: ‣ L. Sachelarie, ‣ A. I. Gasparik
15.11
Conference Room 2.2
OCs2
‣ CAMURATI-ENGELMANN DISEASE WITH SPINAL CORD COMPRESSION: CASE REPORT AND ASSESSMENT OF BONE MICROARCHITECTURE BY HR-PQCT
Presenting author: ‣ C. R. Una
Authors: ‣ M. Belen Zanchetta, ‣ J. J. Rivero, ‣ A. J. Rodriguez, ‣ J. R. Zanchetta, ‣ O. D.  Messina
15.19
Conference Room 2.2
OCs3
‣ REFRACTURE RATE IN FLS IN RIO DE JANEIRO
Presenting author: ‣ B. Stolnicki
Authors: ‣ R. Galdino, ‣ R. Melo, ‣ A. Libman, ‣ H. Maleh
15.27
Conference Room 2.2
OCs4
‣ EFFECT OF MINODRONATE IN PATIENTS WITH LOW BONE MINERAL DENSITY GAIN WHILE USING OTHER BISPHOSPHONATES
Presenting author: ‣ H. Hagino
Authors: ‣ K. Kita, ‣ J. Takada, ‣ N. Yamagata, ‣ M. Ishii
15.35
Conference Room 2.2
OCs5
‣ HOW MAJOR THALASSEMIA AFFECTS ENDOCRINOLOGICAL, BMD AND BONE METABOLISM PARAMETERS: A CROSS SECTIONAL STUDY
Presenting author: ‣ N Panahi
Authors: ‣ B. Larijani, ‣ Z. Hamidi, ‣ A. A. Hamidieh, ‣ M. R. Mohajeri‑Tehrani, ‣ A. Naghghash, ‣ M. Behfar, ‣ F. Mohseni, ‣ K. Alimoghaddam, ‣ H. Rashidian, ‣ A. Ghavamzadeh, ‣ S. Shirazi, ‣ M. Pajouhi
15.43
Conference Room 2.2
OCs6
‣ THE REGISTER OF PATIENTS WITH HIP FRACTURES IN YAROSLAVL, RUSSIAN FEDERATION: THE PRELIMINARY ASSESSMENT
Presenting author: ‣ O. Ershova
Authors: ‣ K. Belova, ‣ A. Degtyarev, ‣ M. Belov, ‣ O. Ganert, ‣ M. Romanova, ‣ I. Abissova
15.51
Conference Room 2.2
OCs7
‣ THE ASSOCIATIONS BETWEEN FEAR OF FALLING, FUNCTIONAL ABILITY AND MUSCLE MASS IN THE ELDERLY
Presenting author: ‣ M. Tamulaitiene
Authors: ‣ A. Mastaviciute, ‣ A. Versalovic, ‣ I. Tamulaityte‑Morozoviene, ‣ V. Alekna
15.59
Conference Room 2.2
OCs8
‣ GENDER DIFFERENCES IN PATIENT INVOLVEMENT IN OSTEOPOROSIS CARE
Presenting author: ‣ A. I. Gasparik
Authors: ‣ D. M. Farcas, ‣ M. L. Cevei
16.07
Conference Room 2.2
OCs9
‣ ASSOCIATION BETWEEN LEAN MASS AND DIETARY PROTEIN INTAKE IN POSTMENOPAUSAL WOMEN
Presenting author: ‣ V. V. Povoroznyuk
Authors: ‣ N. I. Dzerovych, ‣ R. V.  Povoroznyuk
16.15
Conference Room 2.2
OCs10
‣ CHANGES IN QUALITY OF LIFE AFTER FRAGILITY HIP FRACTURES, THAILAND
Presenting author: ‣ T. Sangkomamhang
Author: ‣ U. Sangkomamhang
16.23
Conference Room 2.2
OCs11
‣ THE PREVALENCE OF UNEXPLAINED HBM AMONGST A DXA POPULATION IN AN OSTEOPOROSIS REFERENCE CENTRE FROM ROMANIA
Presenting author: ‣ D. Grigorie
Author: ‣ C. Sucaliuc
16.35
Conference Room 2.2
Presentation of the IOF Committee of National Societies Medal
‣ Jean‑Yves Reginster
17.00 - 18.30
INDUSTRY-SPONSORED SATELLITE SYMPOSIUM
17.00 - 18.30
INDUSTRY-SPONSORED SATELLITE SYMPOSIUM
17.00 - 18.30
Meeting Room 7
ESCEO-IOF-EUGMS-ESPEN SYMPOSIUM - by invitation only
‣ Cohort working group
18.30 - 19.30
Cocktail offered by IOF and ESCEO to all recipients of prizes, awards, fellowships and scholarships - by invitation only